Work on hypocretin, or orexin, as it is also known, is some of the most interesting in all of biology these days. When first characterized a mere three years ago by two groups, it was thought to be involved in feeding (hence the name orexin from the Greek orexis meaning appetite). But two articles exploded […]
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Takeuchi Y, Nagy AJ, Barcsai L, Li Q, Ohsawa M, Mizuseki K, Berényi A (2021) The medial septum as a potential target for treating brain disorders associated with oscillopathies. Front Neural Circuits 15:701080. doi: 10.3389/fncir.2021.701080 Summary: The medial septum (MS) may be a potential target for treating neurological and psychiatric disorders with abnormal oscillations (oscillopathies)
May 12-14, Booth 5067 Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 5067, May 12-14 and find out how you can use Molecular Surgery. Curated Resources Saporin Uses in Immunology Immunology
American Association of Immunologists, AAI 2023 Read More »
In April of this year ATS applied for funding from National Institute for Mental Health (NIMH) for the toxicology studies of Substance P-Saporin (SP-SAP). This $674,000 supplement to a previous NIMH Small Business Innovative Research grant will cover one of the FDA-required safety and toxicology studies and will bring us closer to clinical trials in
Chronic Pain Therapeutic Read More »
Demas GE, Bartness TJ (2001) Novel method for localized, functional sympathetic nervous system denervation of peripheral tissue using guanethidine. J Neurosci Methods 112:21-28. doi: 10.1016/s0165-0270(01)00452-6 Summary: Sympathectomy, or surgical interruption of sympathetic nerve pathways, is an important technique in the analysis of the sympathetic nervous system. The authors investigate and compare several different methods of
Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology
Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts Read More »
Browse our curated resources by topic Animal Models Cancer Research Immunology Neuroscience …more topics being added… Technology Tutorial Video Internalization Technology to eliminate specific cells Still need assistance? Contact us! What do YOU need to calculate? Preparing Kit SamplesCalculate Volumes • MassConvert Molar • Liter
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Botly LC, De Rosa E (2009) Cholinergic deafferentation of the neocortex using 192 IgG-saporin impairs feature binding in rats. J Neurosci 29:4120-4130. doi: 10.1523/JNEUROSCI.0654-09.2009 Summary: It has been hypothesized that the nucleus basalis magnocellularis (NBM) is the source of cholinergic input to the neocortex that is responsible for incorporating different features of an object into
New Secondary Conjugates – Fab-ZAPs – Use Monovalent Secondary Antibodies Linked to Saporin For the past decade scientists have extensively used secondary conjugates (e.g. Mab-ZAP; Cat. #IT-04, and Hum-ZAP; Cat. #IT-22) to make their own targeted toxins for in vitro use. The ability to combine: 1) a primary antibody to a cell-surface marker with 2)
Targeting Tools: Fab-ZAPs Read More »