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Modulation of chronic post-thoracotomy pain by NK-1 neurons in the rostral ventromedial medulla is not paralleled by changes spinal MAPKinase activation.

Strichartz G, Khasabov S, Barr T, Wang J, Simone D (2018) Modulation of chronic post-thoracotomy pain by NK-1 neurons in the rostral ventromedial medulla is not paralleled by changes spinal MAPKinase activation. J Pain 19:S14. doi: 10.1016/j.jpain.2017.12.065 Objective: To evaluate SSP-SAP in treatment of tactile hypersensitivity for Chronic Post-Thoractotomy Pain (CPTP). Summary: SSP-SAP 3 weeks […]

Modulation of chronic post-thoracotomy pain by NK-1 neurons in the rostral ventromedial medulla is not paralleled by changes spinal MAPKinase activation. Read More »

Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning.

Quinlivan M, Chalon S, Vergote J, Henderson J, Katsifis A, Kassiou M, Guilloteau D (2007) Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Neurosci Lett 415(2):97-101. doi: 10.1016/j.neulet.2006.08.065 Summary: The vesicular acetylcholine transporter (VAChT) is a useful imaging target to assess Alzheimer’s disease, since this transporter

Decreased vesicular acetylcholine transporter and alpha(4)beta(2) nicotinic receptor density in the rat brain following 192 IgG-saporin immunolesioning. Read More »

Targeting Tools: FabFc-ZAP – A new secondary conjugate

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Background of General Preparation and Components: Over the last few years, riding on the coattails of the established customer base for the ZAP line of secondary conjugates, Fab-ZAP has become the most popular ATS product group in the catalog. Combining species-specific monovalent secondary antibodies with the cytotoxic ribosome-inactivating protein, Saporin, the Fab-ZAP line of products

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Aptamers

Aptamers Cat # Accession # Description Kd(nM) PRA-008 Q13740 Activated leukocyte cell adhesion molecule .19 Request Quote PRA-002 P36896 Activin receptor type-1B 15 Request Quote PRA-003 P27037 Activin receptor type-2A 1.41 Request Quote PRA-001 Q53SV1 Activin receptor, type I 35.45 Request Quote PRA-009 Q9H6B4 Adipocyte-specific adhesion molecule 4.45 Request Quote PRA-010 P30530 AXL receptor tyrosine

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Efficacy of a murine-p75-saporin immunotoxin for selective lesions of basal forebrain cholinergic neurons in mice.

Nag N, Baxter MG, Berger-Sweeney JE (2009) Efficacy of a murine-p75-saporin immunotoxin for selective lesions of basal forebrain cholinergic neurons in mice. Neurosci Lett 452:247-251. doi: 10.1016/j.neulet.2009.01.006 Summary: The authors tested a new version of mu p75-SAP (Cat. #IT-16) in mice. Mice received bilateral injections of 0.65 or 1.3 µg of immunotoxin into each lateral

Efficacy of a murine-p75-saporin immunotoxin for selective lesions of basal forebrain cholinergic neurons in mice. Read More »

In vivo visualization and molecular targeting of the cardiac conduction system

Goodyer WR, Beyersdorf BM, Duan L, van den Berg NS, Mantri S, Galdos FX, Puluca N, Buikema JW, Lee S, Salmi D, Robinson ER, Rogalla S, Cogan DP, Khosla C, Rosenthal EL, Wu SM (2022) In vivo visualization and molecular targeting of the cardiac conduction system. J Clin Invest e156955. doi: 10.1172/jci156955 Objective: To engineer

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Cover Article: Saporin Immunotoxins for Treating Human Hematological Malignancies

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Contributed by David J Flavell, PhD, The Simon Flavell Leukaemia Research Unit, Division of Cancer Sciences, University of Southampton Medical School, United Kingdom. I have asked Dr. Flavell to contribute an article on the clinical use of his saporin immunotoxins. Dr. Flavell’s research unit is named after his son, who died from leukemia. At that

Cover Article: Saporin Immunotoxins for Treating Human Hematological Malignancies Read More »

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