Targeting Tools: Mouse-Specific p75 Immunotoxin

The long-sought mouse cholinergic toxin has been found! The mouse cholinergic immunotoxin (Cat. #IT-16) is being released for sale at the Society for Neuroscience meeting in New Orleans, November 4-9, 2000! For years ATS has received requests for a molecule that would eliminate cholinergic neurons in the basal forebrain of mice in a manner that […]

Targeting Talk: Second Immunotoxins

What is a second immunotoxin? ATS’s second immunotoxins are conjugations of a secondary antibody (as of December 2000, either goat anti-mouse IgG or goat anti-rabbit IgG) to the ribosome-inactivating protein, saporin. How does a second immunotoxin target? The second immunotoxin uses the secondary antibody to “piggyback” onto your primary antibody in order to evaluate the […]

Targeting Topics 00q4

Impaired acquisition of a Morris water maze task following selective destruction of cerebellar purkinje cells with OX7-saporin. Gandhi CC, Kelly1 RM, Wiley RG, Walsh TJ. Behav Brain Res 109(1):37-47, 2000. PMID: 10699656 The cerebellum has been associated with the control of motor activity and voluntary movements. Recent data have shown the cerebellum may also play […]

Chronic Pain Therapeutic

In April of this year ATS applied for funding from National Institute for Mental Health (NIMH) for the toxicology studies of Substance P-Saporin (SP-SAP). This $674,000 supplement to a previous NIMH Small Business Innovative Research grant will cover one of the FDA-required safety and toxicology studies and will bring us closer to clinical trials in […]

NIDA funds ATS research on Galanin

Advanced Targeting Systems (ATS) has just been awarded a $100,000 research grant from the National Institute on Drug Abuse (NIDA). This Phase I SBIR (Small Business Innovation Research) grant proposes to develop a research reagent to study the function of the neuropeptide, galanin. This will be an important tool for scientists to use in the […]

Cover Article: CBF Lesioning in Rabbits

Contributed by Dr. Thomas Beach, Sun Health Research Institute, Sun City, AZ Our hypothesis, developed through our own human and animal studies1-6 and the cell culture work of others (beginning with Nitsch7), is that the normal, age-related loss of cortical cholinergic innervation leads to Aβ deposition and Alzheimer’s disease. To test this hypothesis, we have been […]

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SP-SAP as Chronic Pain Therapeutic

ADVANCED TARGETING SYSTEMS ANNOUNCES ITS MOLECULAR NEUROSURGERY TECHNOLOGY OPENS DOOR TO PERMANENT RELIEF FOR CHRONIC PAIN SAN DIEGO, CA, NOVEMBER 18, 1999— Chronic, intractable pain afflicts millions of Americans. Pioneering new technology, called molecular neurosurgery and developed by Advanced Targeting Systems, a San Diego-based company, provides the springboard for a one-time injection of a targeted […]

SFN Poster of the Year 1999

Awarded by ATS at Society for Neuroscience (SFN) Miami, Florida • October 23-28, 1999 474.6 Abolition of cyanide-induced sympathoexcitation by selective lesion of bulbospinal catecholaminergic neurons. A.M. SCHREIHOFER* and P.G. GUYENET Univ. of Virginia. Cardiovascular regulation: central control III (POSTER) The rostral ventrolateral medulla (RVLM) contains BS C1 adrenergic cells and non-CA neurons whose relative […]

Abstracts from Society for Neuroscience (SFN) Symposium October 23-28, 1999 – Miami, Florida

271.1 Inhibition of mustard oil-induced thermal hyperalgesia in an operant escape task by substance P-saporin. R.G. WILEY*, D.A. LAPPI and C.J. VIERCK Univ. of Florida Brain Inst. and Adv. Targeting Systems, San Diego. Pain modulation: anatomy and physiology–substance P and NK-1 (POSTER) 272.8 Depletion of IB4-binding sensory neurons results in elevated nociceptive thresholds. L. VULCHANOVA*, […]

Society for Neuroscience (SFN) Symposium October 23-28, 1999 – Miami, Florida

Symposium:  “Exciting New Advances in Pain Research and Treatment Using Receptor Internalization Technologies” D.A. Thomas, NIDA-NIH (co-chair); R.G. Wiley, Vanderbilt University; W.J. Martin, UCSF; M.J. Iadorola, NIDCR-NIH; P. Mantyh, University of Minnesota; R.M. Caudle, University of Florida (co-chair)  A press conference was held prior to the Thursday, Oct. 28 symposium. Carl Hall, journalist for the […]