Crees ZD, DiPersio JF, Persaud SP (2026) Making space for cures: conditioning for autologous hematopoietic stem cell gene therapies. Seminars in Hematology doi: 10.1053/j.seminhematol.2026.09.001
Objective: To define the role transplant conditioning regimens play in autologous gene therapy, including contrasting the goals of care in this setting with those for stem cell transplantation for malignancies.
Summary: The phosphatase CD45 and the tyrosine kinase CD117 are the most frequently targeted antigens in HSCT conditioning studies. CD45-SAP and CD117-SAP were both highly effective at depleting murine HSCs, enabling transplantation between major histocompatibility complex
Related Products: Streptavidin-ZAP (Cat. #IT-27), Anti-CD117-SAP (Cat. #IT-83), Anti-CD45.2-SAP (Cat. #IT-91)
See Also:
- Czechowicz A et al. Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nat Commun 10:617, 2019.
- Palchaudhuri R et al. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol 34:738-745, 2016.