Navarre S, Ishibashi MN, Nair A, Reyes-Torres I, Belabed M, Halasz L, Park MD, Mattiuz R, Ounadjela M, Gunset G, Mansilla-Soto J, Feucht J, Cabriolu A, Le Berichel J, Birbrair A, Eyquem J, Brown BD, Merad M, Sadelain M, Ahmed J (2026) Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases. Nat Cancer 7(7):1104-1120. doi: 10.1038/s43018-026-01167-6 PMID: 42174275
Objective: To investigate strategies to selectively enhance CAR T cell activity at tumor sites to widen the therapeutic window.
Summary: Using syngeneic models of extensive metastatic lung adenocarcinoma and melanoma, the authors showed irradiation increased CAR T cell numbers within tumors but not in adjacent normal lung tissue that also expressed target antigen, conferring robust control of tumor without increased toxicity.
Usage: CD117 was combined with Streptavidin-ZAP (IT-27) and administered at 1 mg kg−1 per recipient to selectively deplete host hematopoietic stem and progenitor cells. In vivo administration of immunotoxin was performed by i.v. injections (300 μl).
Related Products: Streptavidin-ZAP (Cat. #IT-27), Anti-CD117-SAP (Cat. #IT-83)