Dorogin J, Townsend JM, Hettiaratchi MH (2021) Biomaterials for protein delivery for complex tissue healing responses. Biomater Sci 9(7):2339-2361. doi: 10.1039/d0bm01804j
Summary: Delivery of saporin into MCF-7 breast cancer cells using pH-sensitive hyaluronic acid nanogels. MCF-7 cells overexpress CD44, which has a high affinity for hyaluronic acid (HA). This enables binding and subsequent uptake of the coiled-coil peptide-crosslinked HA nanogels (HAcNGs) by MCF-7 cells. Upon endocytosis, HAcNGs dissociate in the acidic conditions of the endosomes of the cell, due to the pH-sensitive dissociation of the crosslinker, releasing saporin.
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