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Intracellular delivery methods using biofunctional peptide-modified extracellular vesicles

Nakase I (2020) Intracellular delivery methods using biofunctional peptide-modified extracellular vesicles. Extracell Vesicles Circ Nucleic Acids 1:44. American Society for Exosomes and Microvesicles 2020 Annual Meeting doi: 10.20517/evcna.2020.10

Summary: Extracellular vesicles (exosomes, EVs) with encapsulation of biofunctional molecules (e.g., enzymes and genes) are highly expected to be next-generation therapeutic carriers because of their pharmaceutical advantages. Saporin-artificially encapsulated EVs with modification of the (sC18)2 peptides showed glycosaminoglycan-dependent cell-killing activity. Our experimental techniques and findings are considered to contribute to the development for EV-based intracellular delivery system via macropinocytosis.

Related Products: Saporin (Cat. #PR-01)