Category: Newsletter

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page.

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Newsletter Highlights

• It’s Twins!(page 2)
• Toxin Safety (page 5)
• OX7-SAP (page 7)

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HCRT-SAP Lesion Produces Sleepiness While anti-DBH-SAP Lesion Does Not  – continued on page 2 and page 6

Carlos Blanco-Centurion contributes this report resulting from work done for an abstract at the 2001 Society for Neuroscience meeting: Hypocretin B-Saporin Lesions of the Brainstem Increase REM Sleep at Night CA Blanco- Centurion, RJ Salin-Pascual, D Gerashchenko, MA Greco, PJ Shiromani. Harvard Medical School & UNAM, Mexico City. This abstract won the ATS Abstract Award. Note: HCRT-SAP is also known as orexin-SAP.

Product information related to cover article: Anti-DBH-SAP (Cat. #IT-03)

SP-SAP (Cat. #IT-07) Licensed to Cell Targeting Technologies

Matthew Kohls Welcomes the Diapered Duo

Recent Scientific References

Targeting Talk: Toxin Safety

• Your recent issue of Targeting Trends stated that it was unlikely that saporin compounds or constituents would be excreted in urine or feces. However, you acknowledge that experimental data is lacking. Have there been any tests of animal urine or feces for saporin content? My animal care staff are concerned.
• Are there any studies which indicate what doses of saporin (by itself or compounded with an antibody) would be hazardous if ingested or injected (i.e. systemic dose level resulting in death or organ dysfunction).

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

Targeting Tools: OX7 and OX7-SAP

• OX7-SAP, Cat. #IT-02
• Antibody to OX7 (anti-Thy 1.1), Cat. #AB-N08

Targeting Technology Tutorial

Targeting Teaser (Jumble)

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Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page.

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Newsletter Highlights

• Party Highlights (page 2)
• Toxin Safety (page 5)
• Serotonin Transporter Antibody (page 7)

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Control Conjugates: The Perfect Companion for Targeted Toxins – continued on page 6

Dr. Douglas Lappi, Chief Scientific Officer, Advanced Targeting Systems

Product information related to cover article: Control Conjugates Catalog

SFN 2001 Abstract Award Winner

ATS Customers Appreciated at Party

Recent Scientific References

Targeting Talk: Toxin Safety

• We’re submitting a protocol to our IACUC to use IB4-SAP (Cat. #IT-10). We plan to inject the targeted toxin and then sacrifice the animal ten days later. What, if any, are the safety issues here?
• Safety Instructions

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

Targeting Tools: Featured Products

• Serotonin Transporter Antibody (Cat. #AB-N09)
• L-Glutamine (Cat. #AB-T13)
• NO-L-Glutamine (Cat. #AB-T14)

Targeting Technology Tutorial

Targeting Teaser (Jumble)

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Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page.

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Newsletter Highlights

• Surfers with a Cause (page 2)
• Time Course of Action (page 5)
• Orexin-SAP (page 7)

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Immunolesioning Hippocampal Inhibitory Interneurons

Dr. Robert Sloviter, University of Arizona, contributes this issue’s article from the laboratories of ATS customers. Dr. Sloviter summarizes his research with SSP- saporin, which he and his graduate student Jennifer Martin used to examine the role of inhibitory neurons in maintaining normal network excitability.

Product information related to cover article: SSP-SAP (Cat. #IT-11)

ATS Receives $900,000 in NIH Funding

Recent Scientific References

Targeting Talk: Time Course of Targeted Toxins

• How long does it take to see the cell death occurring from the use of targeted toxins using saporin? Is there a time course of hours or days?
• Will this time course be the same regardless of the targeted toxin used or the method of administration?
• What are some assays/methods to use to be able to graphically demonstrate cell death?

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

Targeting Tools: Featured Products

• Orexin-SAP, Cat. #IT-20
• Corticotropin Releasing Hormone (CRH/CRF), Cat. #AB-02
• Growth Hormone Releasing Factor (GHRH/GHRF), Cat #AB-01, Cat. #AB-16

Targeting Technology Tutorial

Targeting Teaser (Jumble)

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Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page.

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Newsletter Highlights

• A Field Trip to Torrey Pines State Reserve (page 2)
• Targeted Toxin Delivery (page 5)
• Saporin, a Ribosome-Inactivating Protein (page 7)

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Dermorphin-SAP Kills MOR-Positive Cells

Product information related to cover article: Dermorphin-SAP (Cat. #IT-12)

A Tribute to Thomas J. Walsh, Ph.D.

Going to Work is Like a Walk in the Park

Featured Neuroscience Antibodies: Nerve Growth Factor (p75) Receptor

• NGFR (Cat. #AB-N01) rabbit polyclonal
• NGFR (Cat. #AB-N02) rat monoclonal IgG1
• NGFR (Cat. #AB-N07) mouse monoclonal ME20.4 IgG

Recent Scientific References

Targeting Talk: In Vivo Delivery of Targeted Toxins

• What are the options for delivery of targeted toxins?
• When injecting directly into tissue, are there any special techniques that should be used?
• What sort of special care should be given to the animal after administration of the targeted toxin?

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

Targeting Tools: Featured Products

• Saporin (Cat. #PR-01): a ribosome-inactivating protein

Targeting Technology Tutorial

Targeting Teaser (Jumble)

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Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page.

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Newsletter Highlights

• Cytometry Research partners with Cytomation (page 2)
• Suicide Transport Explained (page 5)
• New Controls for Immunotoxins (page 7)

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Safety Studies Begin for Chronic Pain Therapeutic

San Diego Biotechnology Center Opens

Featured Neuroscience Antibodies

• Mac-1 (Cat. #AB-N05 and Cat. #AB-N06)
• trkA (Cat. #AB-N03)

Recent Scientific References

Targeting Talk: Suicide Transport and Immunolesioning

• What is immunolesioning?
• What is suicide transport?
• How do I administer a targeted toxin to achieve suicide transport?

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

Targeting Tools: Controls for Immunotoxins

• Mouse IgG-SAP, Cat. #IT-18
• Rat IgG-SAP, Cat. #IT-17

Targeting Technology Tutorial

Targeting Teaser (Jumble)

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Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page.

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Newsletter Highlights

• Merging of technology makes everyone a winner (page 1-2)
• Targeted Toxins: Safe, effective in vivo administration (page 5)
• IB4-Saporin, Neuroscience Antibodies (page 7)

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Immunolesioning: From Spinal Cord to Brain

Dr. Ann Schreihofer, University of Virginia, contributes this issue’s article from the laboratories of ATS customers. Dr. Schreihofer summarizes her research with anti-DBH-SAP (Cat. #IT-03) to immunolesion specific rostral ventral medulla neurons that project to the spinal cord by injection of anti-DBH-SAP into the rat spinal cord. The toxin is taken up and retrogradely transported to the cell bodies, eliminates protein synthesis and causes cell death. She examines the effect of neuronal loss on sympathetic nerve activity and arterial pressure.

ATS Joins Forces with Cytometry Research

Jennifer Martin wins “ATS Abstract of the Year Award”

Recent Scientific References

Targeting Talk: In vivo Use of Targeted Toxins

• Can you use targeted toxins in vivo?
• How do you recommend administration of the targeted toxin ?

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

Targeting Tools: New Products

• IB4-Saporin , Cat. #IT-10
• NGFR (Cat. #AB-N01) rabbit polyclonal
• NGFR (Cat. #AB-N02) rat monoclonal IgG1
• NGFR (Cat. #AB-N07) mouse monoclonal ME20.4 IgG

Targeting Technology Tutorial

Targeting Teaser (Jumble)

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Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page.

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Newsletter Highlights

• Toxicology/Safety studies with SP-SAP to begin (page 1-2)
• Second immunotoxins: use your monoclonal or polyclonal to target cells (page 5)
• Mouse p75 immunotoxin to be released at 2000 Society for Neuroscience (SFN) Meeting (page 7)

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CBF Lesioning in Rabbits

contributed by Dr. Thomas Beach, Sun Health Research Institute, Sun City, AZ

Product information related to cover article: ME20.4-SAP, Cat. #IT-15

Chronic Pain Therapeutic

NIDA funds ATS research on Galanin

Recent Scientific References

Targeting Talk: Second Immunotoxins

• What is a second immunotoxin?
• How does a second immunotoxin target?
• What happens when the second immunotoxin gets inside the cell?
• Are there different types of second immunotoxins available?
• What is the ratio of antibody to second immunotoxin for in vitro testing?

Targeting Ticklers (Jokes)

Targeting Teaser Winners from last issue

Targeting Tools: New Products

• Mouse-Specific p75 Immunotoxin (Cat. #IT-16)
• ME20.4 Monoclonal and Immunotoxin (Cat. #IT-15, Cat. #AB-N07)
• Neurotransmitter Antibodies

Targeting Technology Tutorial

Targeting Teaser (Jumble)

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