Targeting Publications

Targeting Topics 03q1

Basal forebrain cholinergic neurons are necessary for estrogen to enhance acquisition of a delayed matching-to-position T-maze task. Gibbs RB. Horm Behav 42(3):245-257, 2002. The author investigated the role of cholinergic neurons of the basal forebrain in cognitive function using a long-term hormone replacement model in rats. Septal infusions of either 1.0 μg or 0.22 μg …

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Targeting Topics 02q4

Unilateral lesions of the cholinergic basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys. Easton A, Ridley RM, Baker HF, Gaffan D. Cereb Cortex 12(7):729-736, 2002. PMID: 12050084 The authors used a combination of basal forebrain lesioning using ME20.4-SAP (Cat. #IT-15) and …

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Targeting Topics 02q3

Impairments in negative patterning, but not simple discrimination learning, in rats with 192 IgG-saporin lesions of the nucleus basalis magnocellularis. Butt AE, Noble MM, Rogers JL, Rea TE. Behav Neurosci 116(2):241-255, 2002. PMID: 11996310 192-Saporin (Cat. #IT-01) administration to the basal forebrain has frequently been used in rats to create a model for Alzheimer’s disease. …

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Targeting Topics 02q2

GABAergic septohippocampal neurons are not necessary for spatial memory. Pang KC, Nocera R, Secor AJ, Yoder RM. Hippocampus 11(6):814-827, 2001. PMID: 11811676 The medial septum and diagonal band of Broca (MSDB) are necessary for spatial memory. Both cholinergic and GABAergic neuronal populations are present in the MSDB. 192-Saporin (Cat. #IT-01) was used to eliminate cholinergic …

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Targeting Topics 02q1

Colocalization of mu-opioid receptors and activated G-proteins in rat cingulate cortex. Vogt LJ, Sim-Selley LJ, Childers SR, Wiley RG, Vogt BA. J Pharmacol Exp Ther 299(3):840-848, 2001. PMID: 11714867 The anterior cingulate cortex (ACC) is a primary site of opiate drug action, and much of this activity is associated with the μ-opioid receptor (MOR). The …

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Targeting Topics 01q4

Focal inhibitory interneuron loss and principal cell hyperexcitability in the rat hippocampus after microinjection of a neurotoxic conjugate of saporin and a peptidase-resistant analog of Substance P. Martin JL, Sloviter RS. J Comp Neurol 436(2):127-152, 2001. PMID: 11438920 The authors used SSP-SAP (0.4 ng/10 nl; Cat. #IT-11). See Cover Story. Selective cholinergic denervation inhibits expression …

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Targeting Topics 01q3

Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin. Zheng F, Khanna S. Neuroscience 103(4):985-998, 2001. PMID: 11301206 Previously, the authors have shown that an injection of formalin in the hindpaw of rats will excite a select population of …

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Targeting Topics 01q2

Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. Haas CA, Hollerbach E, Deller T, Naumann T, Frotscher M. Eur J Neurosci 12(12):4233-4242, 2000. PMID: 11122335 Axonal growth and regeneration is limited in adult mammals, however if injured CNS neurons are in an environment permissive for growth, they can …

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Targeting Topics 01q1

Loss of nerve: a molecular approach to better treatment of chronic pain. Friedrich MJ. JAMA 283(2):187-188, 2000. PMID: 10634324 The use of SP-SAP (Cat. #IT-07) as a promising new method for chronic pain relief is discussed in this review article. Chronic pain has classically been treated in ways that frequently have adverse effects on the …

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Targeting Topics 00q4

Impaired acquisition of a Morris water maze task following selective destruction of cerebellar purkinje cells with OX7-saporin. Gandhi CC, Kelly1 RM, Wiley RG, Walsh TJ. Behav Brain Res 109(1):37-47, 2000. PMID: 10699656 The cerebellum has been associated with the control of motor activity and voluntary movements. Recent data have shown the cerebellum may also play …

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