Targeting Publications

Targeting Topics 15q2

Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations. Kim T, Thankachan S, McKenna JT, McNally JM, Yang C, Choi JH, Chen L, Kocsis B, Deisseroth K, Strecker RE, Basheer R, Brown RE, McCarley RW. Proc Natl Acad Sci U S A 112(11):3535-3540, 2015. Measurements of cortical EEG capture gamma band oscillations (GBO). …

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Targeting Topics 15q1

The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses. Jokiaho AJ, Donovan CM, Watts AG. Diabetes 63(8):2854-2865, 2014. Different sets of glucosensors detect insulin-induced hypoglycemia depending on the onset rate. This detection controls the activation of sympathoadrenal counterregulatory responses (CRRs). Slow onset hypoglycemia, common with …

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Targeting Topics 14q4

Activated Macrophages Create Lineage-specific Microenvironments for Pancreatic Acinar- and beta-cell Regeneration in Mice. Criscimanna A, Coudriet GM, Gittes GK, Piganelli JD, Esni F. Gastroenterology Epub2014. In response to tissue damage or infection, monocytes are recruited to the injured area and differentiate into macrophages. These macrophages can perform different functions depending on the tissue type. The …

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Targeting Topics 14q3

Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat. Alvarez P, Green PG, Levine JD. Pain 155(6):1161-1167, 2014. In order to better understand where monocyte chemoattractant protein 1 (MCP-1) fits in the chronic pain landscape the authors performed a series of experiments using antisense and mismatch oligodeoxynucleotides against the …

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Targeting Topics Top 20

Kilgard MP, Merzenich MM. (1998) Cortical map reorganization enabled by nucleus basalis activity. Science 279(5357):1714-1718. (Cat. #IT-01) – 888 citations Lu J, Sherman D, Devor M, Saper CB. (2006) A putative flip-flop switch for control of REM sleep. Nature 441(7093):589-594. (Cat. #IT-20) – 494 citations Mantyh PW, Rogers SD, Honore P, Allen BJ, Ghilardi JR, …

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Targeting Topics 14q2

Habenular kisspeptin modulates fear in the zebrafish. Ogawa S, Nathan FM, Parhar IS. Proc Natl Acad Sci U S A 111(10):3841-3846, 2014. The peptide kisspeptin can be found in several areas of the brain, but its role in regions other than the hypothalamus has not been studied. Zebrafish express kiss1 mRNA which is a conserved …

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Targeting Topics 14q1

BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer’s disease. Burke RM, Norman TA, Haydar TF, Slack BE, Leeman SE, Blusztajn JK, Mellott TJ. Proc Natl Acad Sci U S A 110(48):19567-19572, 2013. During development bone morphogenetic protein 9 (BMP9) induces the cholinergic phenotype in the basal forebrain. The authors investigated …

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Targeting Topics 13q4

Neurotrophic factors rescue basal forebrain cholinergic neurons and improve performance on a spatial learning test. Lee YS, Danandeh A, Baratta J, Lin CY, Yu J, Robertson RT. Exp Neurol 249C:178-186, 2013. It is thought that therapeutic treatments of the cholinergic system may be a viable treatment for Alzheimer’s disease. In order to examine this hypothesis …

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Targeting Topics 13q3

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Liu Y, Weick JP, Liu H, Krencik R, Zhang X, Ma L, Zhou GM, Ayala M, Zhang SC. Nat Biotechnol 31(5):440-447, 2013. Progenitor cells were transplanted into mice that had received 1.5 μg of mu p75-SAP (Cat. #IT-16) into the …

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Targeting Topics 13q2

Direct Retino-Raphe Projection Alters Serotonergic Tone and Affective Behavior. Ren C, Luan L, Wui-Man Lau B, Huang X, Yang J, Zhou Y, Wu X, Gao J, Pickard GE, So KF, Pu M. Neuropsychopharmacology Epub 2013. Although recent work has shown that some intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible for processing nonimage-forming visual functions, …

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