Targeted Toxins Secondary Conjugates Control Conjugates Saporin Custom Conjugates Selected Antibodies Targeted Toxins: Targeting agent attached to Saporin IT-01 192-IgG-SAP Intracerebroventricular Administration of 192IgG-Saporin Alters the State of Microglia in the Neocortex. Volobueva MN, Dobryakova YV, Manolova AO, Stepanichev MY, Kvichansky AA, Gulyaeva NV, Markevich VA, Bolshakov AP Neurochem J 14(1):37-42, 2020. doi: 10.1134/S1819712420010213 Objective: …
Targeted Toxins Secondary Conjugates Selected Antibodies pHast Conjugates Custom Conjugates Targeted Toxins: Targeting agent attached to Saporin IT-01 192-IgG-SAP Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease (2019) Koshy Cherian A, et al. Psychopharmacol (Berl) Basal forebrain chemogenetic inhibition disrupts the superior complex movement …
TARGETED TOXINS – Targeting agent attached to Saporin IT-01 192-IgG-SAPNeuropharmacology of attention. Burk JA, et al. Eur J Pharmacol 835: 162-168, 2018 Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods. Cho JS, et al. Yonsei Med J 59: (3):406-415, 2018.Intracerebroventricular Administration of …
Photoentrainment and Pupillary Light Reflex Are Mediated By Distinct Populations of Iprgcs. Chen SK, Badea TC, Hattar S. Nature 476(7358):92-95, 2011. PMID: 21765429 Intinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment Melanopsin and regulate a wide array of light dependent physiological processes. Genetic ablation of ipRGCs eliminates circadian photoentrainment and severely disrupts the pupillary …
Neural activity promotes long-distance, target-specific regeneration of adult retinal axons. Lim JH, Stafford BK, Nguyen PL, Lien BV, Wang C, Zukor K, He Z, Huberman AD. Nat Neurosci 19(8):1073-1084, 2016. PMID: 27399843 Axons in the CNS fail to regenerate after injury. Scientists sought to identify strategies that would allow retinal ganglion cell (RGC) axons to …
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Nat Biotechnol 34(7):738-745, 2016. PMID: 27272386 see cover article Retinal Waves Modulate an Intraretinal Circuit of Intrinsically …
The peptidergic control circuit for sighing. Li P, Janczewski WA, Yackle K, Kam K, Pagliardini S, Krasnow MA, Feldman JL. Nature 530(7590):293-297, 2016. PMID: 26855425 Sighs are often associated with relief or sadness, but rodents sigh spontaneously dozens of times per hour. There are physiological benefits to sighing, including enhancement of gas exchange and preservation …
Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain. Navratilova E, Xie JY, Meske D, Qu C, Morimura K, Okun A, Arakawa N, Ossipov M, Fields HL, Porreca F. J Neurosci 35(18):7264-7271, 2015. There are a number of neuronal circuits involved in the processing of pain, including those that control …
Alterations in the rostral ventromedial medulla after the selective ablation of mu-opioid receptor expressing neurons. Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID. Pain 157(1):166-173, 2016. The rostral ventromedial medulla (RVM) has both excitatory and inhibitory control over nociceptive neurons in the medullary dorsal horn and spinal cord. Previous work has demonstrated that …
Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome. Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Proc Natl Acad Sci U S A 112(3):893-898, 2015. Postmortem studies of Tourette syndrome patients has revealed a reduction in …