Kristen Hartman – Page 282 – Advanced Targeting Systems

Cholinergic neurons in the rabbit forebrain: Chemoarchitecture, in vivo labeling, immunolesions

Varga C, Grosche J, Brauer K, Seeger J, Harkany T, Hartig W (2002) Cholinergic neurons in the rabbit forebrain: Chemoarchitecture, in vivo labeling, immunolesions. Neuroscience 2002 Abstracts 35.3. Society for Neuroscience, Orlando, FL. Summary: While the rabbit basal forebrain and its cholinergic components became useful targets for modeling of neuropathological changes associated with Alzheimer’s disease, […]

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Effects of cholinergic deafferentation of rhinal cortex on visual recognition in monkeys

Kristen Hartman

Turchi JN, Saunders RC, Mishkin M (2002) Effects of cholinergic deafferentation of rhinal cortex on visual recognition in monkeys. Neuroscience 2002 Abstracts 82.5. Society for Neuroscience, Orlando, FL. Summary: Excitotoxic lesions of the rhinal (perirhinal/entorhinal) cortices yield substantial deficits in visual recognition (Baxter and Murray, 2001; Malkova et al., 2001). To evaluate the mnemonic role

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Effect of intrathecal substance P-saporin conjugate on bladder hyperactivity induced by intravesical capsaicin

Kristen Hartman

Seki S, Erickson KA, Sasaki K, Sugaya K, Chancellor MB, de Groat WC, Yoshimura N (2002) Effect of intrathecal substance P-saporin conjugate on bladder hyperactivity induced by intravesical capsaicin. Neuroscience 2002 Abstracts 68.2. Society for Neuroscience, Orlando, FL. Summary: Substance P and neurokinin 1 (NK1) receptors in the spinal cord reportedly play an important role

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Lesions of spinothalamic neurons in lumbar spinal cord disrupt ejaculatory reflexes in male rats

Kristen Hartman

Truitt WA, McKenna KE, Coolen LM (2002) Lesions of spinothalamic neurons in lumbar spinal cord disrupt ejaculatory reflexes in male rats. Neuroscience 2002 Abstracts 69.2. Society for Neuroscience, Orlando, FL. Summary: Previously we tested the significance of a population of lumbar spinothalamic (LUST) cells for male sexual behavior in rats. Anatomically, LUST cells are positioned

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Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways.

Kristen Hartman

Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH (2002) Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 5(12):1319-1326. doi: 10.1038/nn966 Related Products: SP-SAP (Cat. #IT-07)

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Efferent projections from the striatal patch compartment: anterograde degeneration after selective ablation of neurons expressing mu-opioid receptor in rats.

Kristen Hartman

Tokuno H, Chiken S, Kametani K, Moriizumi T (2002) Efferent projections from the striatal patch compartment: anterograde degeneration after selective ablation of neurons expressing mu-opioid receptor in rats. Neurosci Lett 332(1):5-8. doi: 10.1016/s0304-3940(02)00837-6 Summary: Taking advantage of the fact that neurons in patch compartments of the striatum express µ-opioid receptors, the authors injected 8.5 ng

Efferent projections from the striatal patch compartment: anterograde degeneration after selective ablation of neurons expressing mu-opioid receptor in rats. Read More »

Spinal neurons that possess the substance P receptor are required for the development of central sensitization.

Kristen Hartman

Khasabov SG, Rogers SD, Ghilardi JR, Peters CM, Mantyh PW, Simone DA (2002) Spinal neurons that possess the substance P receptor are required for the development of central sensitization. J Neurosci 22(20):9086-9098. doi: 10.1523/JNEUROSCI.22-20-09086.2002 Summary: Using 5 x 10-5 M intrathecal injections of SP-SAP (Cat. #IT-07) the authors examined the role of SPR-expressing neurons in

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Motoneuron-derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons.

Kristen Hartman

Bechade C, Mallecourt C, Sedel F, Vyas S, Triller A (2002) Motoneuron-derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons. J Neurosci 22(20):8779-8784. doi: 10.1523/JNEUROSCI.22-20-08779.2002 Summary: In the rat, half of motoneurons die between embryonic day 15 and postnatal day 1. Programmed cell death of interneurons is not as well characterized. The authors cultured

Motoneuron-derived neurotrophin-3 is a survival factor for PAX2-expressing spinal interneurons. Read More »

Custom Antibody-Saporin Conjugates

Kristen Hartman

Q: How do I know my antibody will work in an immunotoxin? A: We recommend that you use one of our second immunotoxins (secondary conjugates) to test for specificity and internalization of your antibody. Q: How much antibody do I need to provide for a custom conjugation? A: The required quantity is 8-15 mg of

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Featured Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat?

Kristen Hartman

Cassel JC (2002) Featured Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat?. Targeting Trends 3(4) Related Products: 192-IgG-SAP (Cat. #IT-01) Read the featured article in Targeting Trends. See Also: Lehmann O et al. 5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat.

Featured Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat? Read More »

Author name: Kristen Hartman