192-IgG-SAP to Examine Episodic Memory

Cholinergic input to the hippocampus is not required for episodic memory in the rat, even with multiple consecutive events.
S. Seel, M.J. Eacott, A. Easton. Behav Brain Res 2017. PMID: 28601587The authors use 192-IgG-SAP (Cat. #IT-01) to examine episodic memory.

  • Continual trials versions of an episodic memory task are unimpaired by cholinergic lesions of the medial septum.
  • In contrast continual trial versions of a location-context (where-which) task are impaired in the same animals.
  • The results replicate the effects of lesions on one-trial a day versions of the same tasks.
  • Increasing the amount of interference between trials by increasing the overlap of features in consecutive events has no effect on the behavioural outcome of these lesions.
  • The result is interpreted in light of models of acetylcholine function centered around pattern separation.