NMB-SAP Kit [KIT-70]

25 ug, 100 ug, 250 ug

a tool for eliminating cells that express Neuromedin B receptor; targeted via Neuromedin B, eliminated via saporin
This kit includes NMB-SAP (Cat. #IT-70) plus Blank-SAP (Cat. #IT-21)

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SKU: KIT-70 Category:

Product Description

Neuromedin B (NMB) and GRP are two members of the mammalian bombesin family of peptides. These two peptides activate structurally similar but pharmacologically distinct G-protein-coupled receptors. NMB is expressed in a subset of sensory neurons that co-label with calcitonin gene-related peptide and TRPV1, suggestive of a role for NMB in nociception. NMB-SAP removes neurons expressing the NMB receptor. In the periphery NMB and GRP have a wide variety of actions including smooth muscle contraction and exocrine and endocrine functions. In the CNS these peptides regulate food intake and body temperature, as well as stress behavioral responses. Additionally, immunolocalization studies showed that NMB protein is present in the dorsal horn of the spinal cord and expression was also seen in sensory neurons.

NMB-SAP eliminates Neuromedin B receptor expressing cells. All other cells are left untouched. It is not suitable for retrograde transport.

To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols

View NMB-SAP Data Sheet
View Blank-SAP Data Sheet

View Related NMB-SAP References
View Related Blank-SAP References

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