Cholecystokinin (CCK) is widely distributed in the central nervous system and the gastrointestinal tract. The 33-amino acid peptide contains a carboxyl terminal octapeptide sequence Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2 which confers the biological activity of CCK, and where the tyrosine residue occurs in sulfated form. This octapeptide, CCK8(SO3), has high affinity for the two structurally-defined CCK receptors types, CCK1 and CCK2. CCK-SAP recognizes and eliminates cells expressing sulfonated CCK. It is not suitable for retrograde transport.
CCK-SAP specifically eliminates cells that recognize sulfonated CCK. All other cells are left untouched. Not suitable for retrograde transport.
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