mu p75-SAP Kit [KIT-16]

25 ug, 50 ug, 100 ug, 250 ug

a tool for eliminating cells that express p75NTR in mouse; targeted via NGFR monoclonal antibody, eliminated via saporin
This kit includes mu p75-SAP (Cat. #IT-16) plus Rabbit IgG-SAP (Cat. #IT-35) and NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

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SKU: KIT-16 Category:

Product Description

Conjugation of a low affinity nerve growth factor receptor (p75NTR) antibody to saporin has produced a cytotoxin that eliminates the CBF neurons, while sparing neighboring neurons that express GAD, calbindin and parvalbumin. mu p75-SAP eliminates cells expressing p75NTR in mouse. Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer’s disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence.

To eliminate p75NTR-expressing cells in rat, use 192-IgG-SAP (Cat. #IT-01). To eliminate p75NTR-expressing cells in other mammals, use ME20.4-SAP (Cat. #IT-15).

mu p75-SAP specifically eliminates p75NTR-positive cells.

IT-16

To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols

View mu p75-SAP Data Sheet
View Rabbit IgG-SAP Data Sheet
View NGFr (mu p75) Rabbit Polyclonal, affinity-purified Data Sheet

View Related mu p75-SAP References
View Related Rabbit IgG-SAP References
View Related NGFr (mu p75) Rabbit Polyclonal, affinity-purified References