Cholera toxin B (CTB) binds the GM1 (Galactosyl-N-Acetylgalactosaminyl) receptor. This receptor is found on cells such as motoneurons, sympathetic pre-ganglionic neurons, as well as cells in the intestinal epithelium. CTB-SAP causes ablation of any cell type expressing GM1, including preganglionic neurons, motoneurons, and astrocytes. Intrathecal injection of CTB-SAP results in elimination of oligodendrocytes and astrocytes and the subsequent demyelination of the spinal cord. CTB-SAP allows the study of a number of demyelinating conditions.
U.S. Patent 6.376,460 “Method of Modulating Cellular Activity” protects methods of peripheral injection of subjects using this neuronal tracer. Before using these methods please contact Flinders Technologies Pty. Ltd. for license information. flinderstech -at- flinders.edu.au
Applications include ablation of any cell type expressing the GM1 receptor, including preganglionic neurons, motoneurons, and astrocytes.
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