192-IgG-SAP Kit [KIT-01]

25 ug, 100 ug, 250 ug

a tool for eliminating cells that express p75NTR in rat; targeted via the antibody to NGFR (192-IgG), eliminated via saporin
This kit includes 192-IgG-SAP (Cat. #IT-01) plus Mouse IgG-SAP (Cat. #IT-18) and NGFr (192-IgG, p75) Mouse Monoclonal (Cat. #AB-N43).

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SKU: KIT-01 Category:

Product Description

Intraventricular injection of 192-IgG-SAP (192-Saporin) results in almost complete elimination of LNGFR (p75NTR)-positive cells in rat. 192-IgG-SAP is directed to a cell-surface antigen that is only expressed at high levels on neurons in the cholinergic basal forebrain (CBF). The antigen, p75NTR, is not expressed on the neighboring, non-cholinergic neurons. 192-IgG-SAP specifically eliminates cholinergic neurons of the basal forebrain, medial septum, diagonal band of Broca, nucleus basalis of Meynert, and Purkinje neurons of the cerebellum. It provides researchers with a powerful lesioning tool – more specific and effective than chemical, surgical or electrolytic lesioning. Permanent and selective removal of cholinergic forebrain neurons makes an important animal model for the study of behavior, neuronal loss (e.g. Alzheimer’s disease), plasticity of other systems in response to loss, replacement therapy, and drug effects and dependence.

LNGFr+ Lesion

To eliminate p75NTR-expressing cells in mouse, use mu p75-SAP (Cat. #IT-16). To eliminate p75NTR-expressing cells in other mammals, use ME20.4-SAP (Cat. #IT-15)).

192-IgG-SAP specifically eliminates cells expressing p75NTR, also known as the low affinity nerve growth factor receptor.

To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols

View 192-IgG-SAP Data Sheet
View Mouse IgG-SAP Data Sheet
View NGFr (192-IgG, p75) Mouse Monoclonal Data Sheet

View Related 192-IgG-SAP References
View Related Mouse IgG-SAP References
View Related NGFr (192-IgG, p75) Mouse Monoclonal References