Rat IgG-SAP serves as a control for targeted conjugates that use a rat monoclonal. Rat IgG-SAP is manufactured in an identical manner as other targeted conjugates, to give a definitive baseline for comparison to the activity of the targeted conjugates listed.
Rat IgG-SAP serves as a control for rat IgG-containing immunolesioning agents.
keywords: saporin, control, IgG, rat, whole
Evaluate Potential Targeting Molecules.
Kohls M (2006) Evaluate Potential Targeting Molecules. Nature Methods
Summary: Targeted toxins -- targeting agents conjugated to saporin -- are widely used to eliminate specific cell populations both in vitro and in vivo. For these molecules to be effective, it is vital that the targeting component of the conjugate specifically binds the cells of interest. A secondary conjugate, Streptavidin-ZAP, has been created by attaching the toxin saporin to streptavidin. The user can combine primary biotinylated material with Streptavidin-ZAP to quickly and economically screen potential targeting molecules for internalization and specificity. Once the appropriate targeting molecule is identified, a direct conjugation with saporin can be performed.
Related Products: Streptavidin-ZAP (Cat. #IT-27)
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