Targeting Article: ATS Receives $900,000 in NIH Funding

In September, Advanced Targeting Systems received two Small Business Innovation Research (SBIR) awards from the National Institutes of Health. The first is a Phase II grant from the National Institute of Neurological Disorders and Stroke. This project continues a collaboration with Drs. Joanne Berger-Sweeney (Wellesley College) and Mark Baxter (Harvard University) to further develop the […]

Cover Article: Immunolesioning Hippocampal Inhibitory Interneurons

Dr. Robert Sloviter, University of Arizona, contributes this issue’s article from the laboratories of ATS customers. Dr. Sloviter summarizes his research with SSP-saporin, which he and his graduate student Jennifer Martin used to examine the role of inhibitory neurons in maintaining normal network excitability. The mammalian hippocampus is perhaps the most intensely studied brain region […]

Targeting Trends Newsletter 01q3

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights A Field Trip to Torrey Pines State Reserve (page 2) Targeted Toxin Delivery (page 5) Saporin, a Ribosome-Inactivating Protein (page 7)

Targeting Tools: Saporin – a ribosome-inactivating protein

Saporin is a 30 kDa protein isolated from the seeds of the plant Saponaria officinalis. This pleasant resident of the banks of Southern European streams has long been known for medicinal properties, mainly due to its saponins, detergents that reside especially in the roots of the plant and which give the plant its name. It […]

Targeting Talk: In Vivo Delivery of Targeted Toxins

What are the options for delivery of targeted toxins? The options for toxin delivery are varied and limited only by investigator ingenuity. Generally, injection has been the route of choice. Some toxins can be given intravenously, such as 192-Saporin (192-IgG-SAP, Cat. # IT-01) or anti-DBH-SAP (Cat. # IT-03), in which case all cells expressing p75 […]

Targeting Topics 01q3

Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin. Zheng F, Khanna S. Neuroscience 103(4):985-998, 2001. PMID: 11301206 Previously, the authors have shown that an injection of formalin in the hindpaw of rats will excite a select population of […]

Cover Article: Dermorphin-SAP Kills MOR-Positive Cells

Advanced Targeting Systems announces the release of its new, very exciting targeted toxin, dermorphin-SAP. It is a conjugate of the mu opioid receptor (MOR) agonist dermorphin and the ribosome-inactivating protein, saporin. Its cytotoxicity to cells that express the MOR promise to make it an important tool in the discovery and definition of the role of […]

Targeting Trends Newsletter 01q2

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Cytometry Research partners with Cytomation (page 2) Suicide Transport Explained (page 5) New Controls for Immunotoxins (page 7)

Targeting Tools: Controls for Immunotoxins

Advanced Targeting Systems announces two new control molecules for use with immunotoxins. We now offer mouse IgG (Cat. #IT-18) or rat IgG (Cat. #IT-17) conjugated to saporin. These new controls are the same molecular weight, consist of similar, comparable materials — saporin and a rat or mouse IgG — and are synthesized with the same […]

Targeting Talk: Suicide Transport and Immunolesioning

What is immunolesioning? Immunolesioning is a technique for making highly selective cellular lesions using immunotoxins. The immunotoxins consist of a monoclonal antibody to a cell surface molecule and a toxic effect or moiety such as saporin, a ribosome-inactivating protein. The selectivity of the lesion made with this technique depends on the selective expression of the […]