Targeting Trends Newsletter 17q1

Below are links to view the quarterly newsletter Targeting Trends. You can also download the full PDF here. If you would like to be added to the mailing list, please subscribe here.

Lipid Link to Neuro-Degenerative Disease

Martínez-Gardeazabal J et al. Lipid mapping of the rat brain for models of disease. Biochim Biophys Acta. 2017 Feb 21. [Epub ahead of print] PMID:28235468 The major components of plasma membranes are lipids. These molecules have a wide range of functions including cellular structure, metabolism and signaling molecules.  Regarding this last feature, there is a group […]

Targeting Topics 17q1

Photoentrainment and Pupillary Light Reflex Are Mediated By Distinct Populations of Iprgcs. Chen SK, Badea TC, Hattar S. Nature 476(7358):92-95, 2011. PMID: 21765429 Intinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment Melanopsin and regulate a wide array of light dependent physiological processes. Genetic ablation of ipRGCs eliminates circadian photoentrainment and severely disrupts the pupillary […]

Melanopsin photoresponse relies on the SEE-terminus

Somasundaram et al. C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice. PNAS (2017), pii: 201611893. PMID: 28223508 Chronotype (morningness-eveningness) in mammals likely has multiple causes. Phase angle of entrainment is defined as the relationship between the timing of the biological clock and the timing of an external time cue, and if the primary […]

Targeting Talk: Neurotransmitter Antibodies

Advanced Targeting Systems offers a full line of antibodies to neurotransmitters; everything from serotonin and L-DOPA, to noradrenaline and dopamine. These antibodies are an excellent choice for immunohistochemistry applications as they are ideally primed for use in tissues that have been perfused with a mixture of paraformaldehyde and gluteraldehyde. Some frequently asked questions: Q:  Could you […]

Neurovascular Coupling and Brain Imaging

Lecrux et al. Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. Journal of Neuroscience (2017), 1784-16. PMID: 28069927 Brain imaging techniques that use vascular signals to map changes in neuronal activity rely on the coupling between electrophysiology and hemodynamics, a phenomenon referred to “neurovascular coupling” (NVC). It is unknown whether […]