Targeted Toxins for Neuroscience Antibody Screening for Neuroscience There is a growing need for therapeutics for cancer, autoimmune diseases, blood diseases and Alzheimer’s disease. Due to their ability to bind to a specific target antigen, monoclonal antibodies are increasingly being screened for therapeutic drug development. In May 2021, the FDA approved the 100th monoclonal antibody […]
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One of the more common methods of using Streptavidin-ZAP is to couple the complex with biotinylated antibodies. However, there are also many instances of biotinylated ligands, peptides, and even biotinylated major histocompatibility complex (MHC) tetramers in immunology fields. B-Cell Targeting. An example of utilizing Streptavidin-ZAP to study ligands that target CD22 were shown by Collins
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NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07) The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective
ATS Animal Models ATS offers many different Animal Model products and full kits for various disease and behavioral research applications. Animal Models Learn more about our Saporin-produced Animal Models. Choose the product links below for the Animal Model of your interest. Most Animal Models are ready in 2 weeks using our Saporin conjugate system to
pHast Conjugates pHast Conjugates are one of our pHastest tools for quantitative testing of your primary antibody’s specificity, binding, and internalization, providing results in 1 day. How It Works The pHast conjugate binds to your primary antibody via a secondary antibody cross-linked to a pH-dependent fluorescent reporter. This fluorescent reporter will increase intensity as the
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NGFR Antibodies ATS has 3 NGFR antibodies that work in different species NGFR Intro Also available in Chinese | French | German | Italian | Japanese | Korean | Portuguese | Spanish NGFR Video 02 Also available in Chinese | French | German | Italian | Japanese | Korean | Portuguese | Spanish AB-N01 AB-N01
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This manuscript describes the myriad of ways Streptavidin-ZAP is used and how this technology supports the scientific process of ‘Molecular Surgery’ and progress in research and drug development. Insights from publications and research performed using Streptavidin-ZAP and its impact on academia and industry for research and drug development are presented. Read the full article as
Streptavidin-saporin: Converting biotinylated materials into targeted toxins Read More »
192-IgG-SAP (targets NGFR+ cells) Anti-DBH-SAP (targets dopamine beta hydroxylase)
Alzheimer’s Disease Research Read More »
Summary: These results indicate a prominent role of NA-neurons vs. ACh ones in impairments of working memory, relevant for Alzheimer’s Disease. Usage: Bilateral icv injection of 192-IgG-SAP and/or Anti-DBH-SAP. G. Leanza and R. Zorec. Function 2023, 4(1) DOI: 10.1093/function/zqac060. We would be pleased to send you our 2023 ATS calendar. Click here to provide us your
Saporin Publication highlighting 192-IgG-SAP and Anti-DBH-SAP Read More »
ABSTRACT When investigating the origins of targeted toxins (a drug, therapy, or scientific tool directed to unique extracellular target), an appropriate place to begin is with the Nobel Prize-winning work of Paul Ehrlich and his concept of the “magic bullet.” Over 100 years later, the use of targeted toxins to perform molecular neurosurgery has become
A Brief History of Saporin and its Contributions to Neuroscience Read More »