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CD11b Targeting Tools

Ferrini F, Trang T, Mattioli TA, Laffray S, Del’Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, De Koninck Y. (2013) Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl- homeostasis. Nat Neurosci 16:183-92.

To Itch or Not to Itch

Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. (2017) Molecular and Neural Basis of Contagious Itch Behavior in Mice. Science 355(6329):1072-76. PMID: 28280205 Observing others scratch themselves can make you want to do so.  This contagious itching has been observed in monkeys and humans, but what about rodents?  Yu et al. found that […]

Lipid Link to Neuro-Degenerative Disease

Martínez-Gardeazabal J, González de San Román E, Moreno-Rodríguez M, Llorente-Ovejero A, Manuel I, Rodríguez-Puertas R. (2017) Lipid Mapping of the Rat Brain for Models of Disease. Biochim Biophys Acta  PMID:28235468 The major components of plasma membranes are lipids. These molecules have a wide range of functions including cellular structure, metabolism and signaling molecules.  Regarding this […]

Targeting Topics 17q1

Photoentrainment and Pupillary Light Reflex Are Mediated By Distinct Populations of Iprgcs. Chen SK, Badea TC, Hattar S. Nature 476(7358):92-95, 2011. PMID: 21765429 Intinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment Melanopsin and regulate a wide array of light dependent physiological processes. Genetic ablation of ipRGCs eliminates circadian photoentrainment and severely disrupts the pupillary […]

Melanopsin photoresponse relies on the SEE-terminus

Somasundaram et al. C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice. PNAS (2017), pii: 201611893. PMID: 28223508 Chronotype (morningness-eveningness) in mammals likely has multiple causes. Phase angle of entrainment is defined as the relationship between the timing of the biological clock and the timing of an external time cue, and if the primary […]

Neurovascular Coupling and Brain Imaging

Lecrux et al. Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. Journal of Neuroscience (2017), 1784-16. PMID: 28069927 Brain imaging techniques that use vascular signals to map changes in neuronal activity rely on the coupling between electrophysiology and hemodynamics, a phenomenon referred to “neurovascular coupling” (NVC). It is unknown whether […]