Targeting Trends

Cover Article: Targeted Toxins – Cheaper and Quicker than Knockouts

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Cell-specific targeting and removal: cheaper and quicker than knockouts with high impact results. Knockout models are helpful tools in scientific research. They have been useful in studying and modeling in all sorts of research in biology; so much so that the pioneers – Smithies, Capecchi and Evans – won a well-deserved Nobel Prize for Physiology […]

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Call for Proposals

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Advanced Targeting Systems and its Contract Service partner, CytoLogistics announce a Call For Proposals for research collaborations on: Receptor-mediated Delivery: New Targets Selected researchers will receive support for smaller scale or pilot research projects ($1,000 – $25,000) with the targeting tools and contract services needed for the identification and characterization of new cell-surface markers for

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Targeting Tools: Top Twenty of 2018

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Top Five Targeted Toxins 1. CTB-SAP (Cholera Toxin B-Saporin) (Cat. #IT-14) – targets cells expressing GM1 receptor 2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH) 3. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR 4. Anti-ChAT-SAP (Cat. #IT-42) – targets cells expressing choline acetyltransferase 5. Nppb-SAP (Neuropeptide natriuretic polypeptide

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Impaired reach-to-grasp responses in mice depleted of striatal cholinergic interneurons

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by Nilupaer Abudukeyoumu, Marianela Garcia-Munoz, Yoko Nakano, Gordon W. Arbuthnott.Brain Mechanism for Behavior Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan Cholinergic interneurons (ChIs) are sparsely distributed within the striatum, a nucleus that plays important roles in voluntary motor control, associated learning, procedural memory, execution of movement, action selection, and planning.[1] ChIs

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Targeting Trends 2018 Review

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Read the complete 2018 Review and recent Scientific References Impaired reach-to-grasp responses in mice depleted of striatal cholinergic interneurons. / by N Abudukeyoumu et al. / featuring Anti-ChAT-SAP, Cat. #IT-42 2018 Poster of the Year Award Product Managers Targeting Tools: Top Twenty of 2018 Call For Proposals for research collaborations on Receptor-mediated Delivery: New Targets

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ZAP Antibody Internalization Kits

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ZAP Antibody Internalization Kits allow a large number of antibodies to be screened quickly and cost-effectively for specificity, functional binding, internalization, and EC50 determination.  The wide selection of these secondary conjugates provide ideal tools for screening potential antibodies . They are constructed using either species-specific polyclonal anti-IgG antibodies, or streptavidin (alternate kit for use with biotinylated

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Fab-pHAST: The newest targeting tool

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Contributed by Patrick Shramm, Product Manager for Fab-pHast We are pleased to announce a new set of tools to rapidly screen antibodies, Fab-pHast conjugates. The ATS pHAST product line provides the FASTEST results in quantitative testing of your antibody’s specific-binding and internalization. Fab-pHast contains a pH-dependent fluorescent reporter that increases intensity in acidic surroundings, such

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Cover Article: The locus coeruleus: a potential link between cerebrovascular and neuronal pathology in Alzheimer’s disease.

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Contributed by S C Kelly, P T Nelson, S E Counts Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that most commonly affects individuals over the age of 65. While of unknown etiology, AD is characterized by a steady decline in cognitive functions including memory, attention, executive functions, and language. There is currently no disease-modifying therapy

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