Alzheimer’s Disease Products TARGETED TOXINS Tools for Eliminating Cells that Express a Cell Surface Marker 192-IgG-SAP – targets cells expressing LNGFR in rat (Cat. #IT-01) mu p75-SAP – targets cells expressing LNGFR in mouse (Cat. #IT-16) ME20.4-SAP – targets cells expressing LNGFR in various species (Cat. #IT-15) Anti-ChAT-SAP – targets cells expressing choline acetyltransferase (Cat. […]
Cholinergic input to the hippocampus is not required for episodic memory in the rat, even with multiple consecutive events. S. Seel, M.J. Eacott, A. Easton. Behav Brain Res 2017. PMID: 28601587The authors use 192-IgG-SAP (Cat. #IT-01) to examine episodic memory. Continual trials versions of an episodic memory task are unimpaired by cholinergic lesions of the medial septum. In contrast continual trial versions […]
Research Update Sonic Hedgehog and TDP-43 Participate in the Spontaneous Locomotor Recovery in a Mouse Model of Spinal Motoneuron Disease. Rosario Gulino *, Rosalba Parenti and Massimo Gulisano J. Funct. Morphol. Kinesiol. 2017, 2(2), 11; doi:10.3390/jfmk2020011 The authors used a mouse model of neurotoxic motoneuron depletion to study the role of Sonic hedgehog and TDP-43 in the compensatory […]
Research Update Role of A5 noradrenergic neurons in the chemoreflex control of respiratory and sympathetic activities in unanesthetized conditions. Camilia L Taxini, Thiago S Moreira, Ana C Takakura, Daniel B Zoccal. Neuroscience 2017 Jun 23;354:146-157. doi: 10.1016/j.neuroscience.2017.04.033. Epub 2017 Apr 29. The authors utilize Anti-DBH-SAP (Cat. #IT-03) to investigate the involvement of the A5 noradrenergic neurons to […]
Targeting Cholinergic Neurons with 192-IgG-SAP
Ferrini F, Trang T, Mattioli TA, Laffray S, Del’Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, De Koninck Y. (2013) Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl- homeostasis. Nat Neurosci 16:183-92.
ZAP Antibody Internalization Kits contain all of the materials needed to screen your antibody. Included, in addition to the selected ZAP products, are controls and developing reagents for the assay. All the user provides are the materials specific to their experiment (the antibody candidate, cells expressing the target, and culture reagents). Recommended protocols for use […]
Q: Your targeted toxin kits come with different controls. I’m not sure of the best way to use them; there is included unconjugated antibody, unconjugated saporin, and a control conjugate, mouse IgG-SAP. Should I use them all in the same experiment or for different purposes? A: For mouse IgG-containing conjugates, the ideal control is Mouse […]