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CD11b Targeting Tools

Ferrini F, Trang T, Mattioli TA, Laffray S, Del’Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, De Koninck Y. (2013) Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl- homeostasis. Nat Neurosci 16:183-92.

ZAP Antibody Internalization Kits

ZAP Antibody Internalization Kits contain all of the materials needed to screen your antibody.  Included, in addition to the selected ZAP products, are controls and developing reagents for the assay.  All the user provides are the materials specific to their experiment (the antibody candidate, cells expressing the target, and culture reagents). Recommended protocols for use […]

Targeting Talk: Using Kit Controls

Q: Your targeted toxin kits come with different controls. I’m not sure of the best way to use them; there is included unconjugated antibody, unconjugated saporin, and a control conjugate, mouse IgG-SAP. Should I use them all in the same experiment or for different purposes? A: For mouse IgG-containing conjugates, the ideal control is Mouse […]

Booth

Targeted Toxins featured at FASEB Meeting

Chicago April 22-26, 2017 Four posters feature ATS products at next week’s Experimental Biology meeting. Stop by Booth 462 to find out more! Adenosine 2A (A2A) receptor expression in rats with motor neuron death from intrapleural CTB-saporin injections. Taylor A. Craig, Scott M. Brown, and Nicole L. Nichols.  FASEB J April 2017 31:873.14.  Experimental Biology […]

To Itch or Not to Itch

Yu YQ, Barry DM, Hao Y, Liu XT, Chen ZF. (2017) Molecular and Neural Basis of Contagious Itch Behavior in Mice. Science 355(6329):1072-76. PMID: 28280205 Observing others scratch themselves can make you want to do so.  This contagious itching has been observed in monkeys and humans, but what about rodents?  Yu et al. found that […]

Targeting Trends Newsletter 17q1

Below are links to view the quarterly newsletter Targeting Trends. You can also download the full PDF here. If you would like to be added to the mailing list, please subscribe here.

Lipid Link to Neuro-Degenerative Disease

Martínez-Gardeazabal J, González de San Román E, Moreno-Rodríguez M, Llorente-Ovejero A, Manuel I, Rodríguez-Puertas R. (2017) Lipid Mapping of the Rat Brain for Models of Disease. Biochim Biophys Acta  PMID:28235468 The major components of plasma membranes are lipids. These molecules have a wide range of functions including cellular structure, metabolism and signaling molecules.  Regarding this […]

Targeting Topics 17q1

Photoentrainment and Pupillary Light Reflex Are Mediated By Distinct Populations of Iprgcs. Chen SK, Badea TC, Hattar S. Nature 476(7358):92-95, 2011. PMID: 21765429 Intinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment Melanopsin and regulate a wide array of light dependent physiological processes. Genetic ablation of ipRGCs eliminates circadian photoentrainment and severely disrupts the pupillary […]