Author name: Kristen Hartman

2019 Poster of the Year

Congratulations to Dr. Argyle Bumanglag and the team at University of Florida for the important work they presented using SSP-SAP to create an animal model of temporal lobe epilepsy. Injections of SSP-SAP into the hippocampus of a rat causes acute hippocampal injury, permanent dentate granule cell-onset epilepsy, and hippocampal sclerosis that closely resembles the selective …

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Renal denervation for treating congenital long QT syndrome: Shortening the QT interval or modulating sympathetic tone?

Kiuchi MG, Chen S, Carnagarin R, Matthews VB, Schlaich MP (2019) Renal denervation for treating congenital long QT syndrome: Shortening the QT interval or modulating sympathetic tone?. Europace 21(11):1755-1756. doi: 10.1093/europace/euz251 Summary: Targeted ablation of cardiac sympathetic neurons (TACSN) through CTB-SAP injection in the left stellate ganglion (LSG), inhibited its activation, improved sympathetic remodelling, and …

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Corticolimbic stress regulatory circuits, hypothalamo–pituitary–adrenocortical adaptation, and resilience

Herman JP (2020) Corticolimbic stress regulatory circuits, hypothalamo–pituitary–adrenocortical adaptation, and resilience. Chen A (Ed.): Stress Resilience 291-309. Academic Press doi: 10.1016/B978-0-12-813983-7.00019-7 Summary: Review. Immunolesion of paraventricular nucleus (PVN)-projecting norepinephrine (NE) neurons with Anti-DBH-SAP attenuates acute stress reactivity (interestingly, to restraint), but it does not inhibit somatic or HPA axis responses to stress in any simple …

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Sign-trackers deploy perceptual, but not cholinergic-attentional, mechanisms to respond to salient cues

Phillips KB, Avila C, Sarter M (2019) Sign-trackers deploy perceptual, but not cholinergic-attentional, mechanisms to respond to salient cues. Neuroscience 2019 Abstracts 331.10. Society for Neuroscience, Chicago, IL. Summary: Sign-trackers (STs) attribute incentive value to stimuli that predict food and drug rewards and therefore have emerged as a model for studying vulnerability for addiction-like behaviors. …

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Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris water maze and object-place paired association tasks

Truckenbrod LM, Bumanglag AV, Chun E, Hernandez A, Federico QP, Maurer AP, Sloviter RS, Burke SN (2019) Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris water maze and object-place paired association tasks. Neuroscience 2019 Abstracts 158.03. Society for Neuroscience, Chicago, IL. Summary: An epileptogenic role for hippocampal GABAergic …

Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris water maze and object-place paired association tasks Read More »

Exercise is neuroprotective following partial motoneuron depletion via androgen action at the target muscle

Chew C, Sengelaub DR (2019) Exercise is neuroprotective following partial motoneuron depletion via androgen action at the target muscle. Neuroscience 2019 Abstracts 134.13. Society for Neuroscience, Chicago, IL. Summary: We have previously demonstrated that partial depletion of motoneurons innervating the quadriceps muscles induces dendritic atrophy in remaining motoneurons. Furthermore, systemic treatment with supplemental androgens is …

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